La i-quercetin Kungokweqembu lezinto ze-polyphenolic ezaziwa ngokuthi ama-flavonoids.

Ama-Flavonoid atholwa usosayensi waseHungary u-Albert Szent-Györgyi, owathola uvithamini C (wathola umklomelo kaNobel wezokwelapha kanye ne-physiology ngo-1937), owabona lokho. ama-flavonoid anomphumela we-synergistic ne-vitamin C.

I-Quercetin iyi-molecule ye-polyphenolic ekhiqizwa yi-metabolism yezinye izitshalo ezifana ne-horse chestnut, i-calendula, i-hawthorn, i-chamomile, i-St. John's wort ne-ginkgo biloba, kodwa nezithelo, imifino, amaqabunga, imbewu kanye nokusanhlamvu.

Izakhiwo zibaliwe ama-antioxidants kanye ne-anticancer, phakathi kwabanye.

Singayithola kuphi i-quercetin?

I-Quercetin isakazwa kabanzi embusweni wezitshalo: siyayithola ezithelweni, emakhasini kanye nama-rinds yama-apula no-anyanisi, ukhokho, izithelo ezibomvu kanye ne-broccoli. Imithombo ecebile ikakhulukazi izithelo ezisawolintshi, amafutha omnqumo, u-anyanisi, iwayini elibomvu, itiye eliluhlaza kanye ne-St. John's wort.

I-quercetin evame ukusetshenziswa ezithasiselweni zokudla ikhishwa efihlekile shopora japonica (isitshalo somndeni UFabaceae – Indumba) eyaziwa nangokuthi I-Robinia yaseJapane, Umtholo waseJapane noma umuthi we-pagoda. Isitshalo, esidabuka e-Asia (eChina naseKorea), ikhula ezindaweni ezifudumele nezipholile futhi isabalele nasezifundeni zesimo sezulu esishisayo sase-Europe.

Kusukela shopora japonica icebile kakhulu nge-quercetin, kungenzeka ukuthola i-extract ehlanzekile. I-Quercetin ibaluleke kakhulu isetshenziselwa izifo ze-metabolic kanye nokuvuvukala futhi umsebenzi oyinhloko okuthiwa yi-antioxidant.

Eqinisweni, kusiza ukunciphisa ukwakheka kwama-radicals mahhala kanye nezinto ezikhuthaza ukuvuvukala, okufakazela ukuthi ungumlingani obalulekile wempilo yethu. Ngaphezu kwalokho, izakhiwo zibhekwa yikho I-vasoactive, ngoba inyusa ukumelana kwama-capillaries futhi ilawula ukungena kwawo.

I-Quercetin Effects

I-Quercetin inemisebenzi elandelayo:

• anti-inflammatory,
• i-antiestrogenic,
• ukunciphisa ukwakheka kwezicubu ze-endometrial,
• ukwehla okukhulu komfutho wegazi we-systolic ezigulini ezisemngceleni, ikakhulukazi uma zikhuluphele,
• i-antiatherosclerotic ngokuvimbela i-LDL oxidation kanye nokulimala kwe-arterial endothelial,
• ukuvikelwa kwenhliziyo,
• i-antiviral,
• i-immunomodulator,
• i-anti-allergenic,
• i-gastroprotective.

Ithathwa kanjani i-quercetin?

I-Quercetin imuncwa emathunjini futhi ama-metabolites ayo asatshalaliswa yisibindi ezicubu ezihlukahlukene zomzimba. Ku-plasma ibophezela ku-albumin. I Inani eliphakeme le-plasma lifinyelelwa cishe amahora angama-7 ngemuva kokungeniswa futhi ukuqeda uhhafu wempilo cishe amahora angama-25. Ukutholakala kwe-quercetin ngomlomo akuqinisekisiwe: empeleni, kubonakala sengathi i-quercetin ingcono futhi ifakwe ngokufana emathunjini uma ithathwa kanye namafutha afana ne-medium chain triglycerides. Kungakho kubalulekile ukuthi izithasiselo ziqukethe izinto ezingama-lipid futhi zithathwe esiswini esigcwele.

Njengoba kunikezwe ukuthi izifundo zesayensi zibonise ukuthi ukudla okuphezulu kwe-flavonoids kunciphisa ingozi yezifo zenhliziyo nokuthi i-quercetin itholakala kakhulu ekudleni kwethu, kuhle ukudla izithelo nemifino nsuku zonke.

Uma empeleni inani elanele le-polyphenols lingathathwanga noma ezimweni ezithile zezempilo lapho kudingekile ukuba lithathwe ngamanani amakhulu, ukusetshenziswa kwezithako zokudla kungabhekiselwa kukho inqobo nje uma kuqukethe okukhishwe okujwayelekile, okune-titrated okuhlotshaniswa nabagqugquzeli bokumuncwa. lokho kuthanda ukufanisa.

Ekwengezeni, inani eliphezulu lokudla kwansuku zonke elivunyelwe uMnyango Wezempilo ngu 200 mg nsuku zonke kodwa, ngenxa yokusetshenziswa kweminye imikhiqizo yezinto ezikhuthaza ukumuncwa kwayo, inani eliphansi liyokwanela.

Iyini imithombo yemvelo ye-quercetin?

I-Quercetin ingenye ye-flavonoid yokudla etholakala kakhulu, kangangokuthi isilinganiso sokudla kwansuku zonke ngokudla okuvamile silinganiselwa ku-25-50 milligrams.

Okunye ukudla/ukudla okuphezulu kakhulu ku-quercetin kufaka:

• ama-capers (ngokuphathelene nesisindo, yisitshalo esiqukethe kakhulu, 234 mg nge-100 g yama-buds eluhlaza),
• i-buckwheat,
• amagilebhisi amhlophe/abomvu
• iwayini elibomvu (empeleni, emagilebhisini, lokhu kuhlanganiswe kuzo zombili izinhlobo ezimhlophe nezibomvu, kodwa mayelana newayini, ligxile ngaphezu kwakho konke ewayinini elibomvu ngenxa yenqubo yokuguqulwa)
• U-anyanisi obomvu,
• Itiye Elihlaza,
• amajingijolo,
• I-apula,
• i-propolis,
• isilimo esidliwayo esinamagatsha anamanzi,
• isithombo,
• iklabishi.
• ama-apula,
• amagilebhisi,
• ikhofi,
• amajikijolo,
• i-broccoli,
• izithelo ze-citric,
• kanye nama cherry.

Iningi lama-flavonoid ekudleni avela ku-quercetin.

I-quercetin etholakala kakhulu ye-bioavailable ngakho-ke ifaniswe kangcono yileso sesikhumba se-apula.

Ungawalahli amagobolondo

Kuyafaneleka ukukhumbula ukuthi ku-anyanisi obomvu ukugxila okuphezulu kakhulu kwe-quercetin akutholakali kuphela engxenyeni eseduze nempande, ingxenye yesitshalo enezinga eliphezulu kakhulu, kodwa nasemasongweni angaphandle. Lesi simo sivame kakhulu emvelweni futhi siwumthetho okungafanele ukhohlwe ekhishini, ikakhulukazi lapho sinecala sisusa ama-peels kanye nezingqimba zangaphandle zemifino nezithelo kalula, sikhohlwe ukuthi zimelela imithombo ebaluleke kakhulu yezinto eziphilayo.

El ukusetshenziswa kokudla okunamafutha kanye nemithombo yokudla ye-quercetin kubonakala kukwazi ukukhulisa ukumuncwa kwayo ngempumelelo, yona ngokwayo ilinganiselwe. Futhi ukuba khona kwama-carbohydrates, ngenxa yokukhuthazwa kwe-motility yamathumbu kanye nezimo zokuvutshelwa emathunjini, kungaba nomthelela omuhle kulokhu.

I-quercetin iwathinta kanjani amasosha omzimba?

Le nto inezinto ezilwa namagciwane ezisekelwa izifundo ezihlukahlukene kumamodeli ezilwane, kodwa ngeshwa kuze kube manje asiwazi umphumela wangempela kanye nesenzo sale nto kumasosha omzimba.

Sengiphetha, ezinye izinkolelo-mbono zikholelwa ukuthi kungaba inzuzo kuphela ngaphansi kwezimo ezithile ukucindezeleka kwengqondo okwedlulele.

Isetshenziselwani i-quercetin?

Phakathi kwezinkomba ezisetshenziswa kakhulu yizindawo zayo zokulwa nokuvuvukala kanye ne-antioxidant, okuholele ekusetshenzisweni kwayo ezindaweni eziningi zezokwelapha nangezinhloso ezahlukahlukene:

• ukwesekwa kwamasosha omzimba,
• ukunciphisa ukuvuvukala,
• ukusebenza kwe-antitumor (ngaphezu kokuvimbela),
• ukulawula ushukela wegazi,
• ukwesekwa kokusebenza kwezemidlalo
• ukuvimbela izifo zenhliziyo.

Izimpawu ezincane zihlanganisa:

• isifo samathambo,
• i-cystitis ye-interstitial,
• i-prostatitis.

I-Quercetin iye yacwaningwa ocwaningweni oluyisisekelo (i-in vitro, okungukuthi, kumashubhu okuhlola noma emngceleni wamamodeli ezilwane) nasezivivinyweni ezincane zomtholampilo (kubantu), kodwa ngenkathi izithasiselo zivame ukukhuthazwa ukuze zelashwe umdlavuza nezinye izifo zikhona okwamanje. ubufakazi obanele bekhwalithi eyanele ukukhombisa ukusebenza kahle okulinganisekayo kwangempela.

Ungayithatha kanjani futhi nini i-quercetin uma uqhuba imidlalo?

I-Quercetin supplementation ingase isekele kancane ukusebenza kokuzivocavoca kokumelana.

Ingabe i-quercetin inesenzo sokulwa ne-antioxidant?

Umsebenzi omuhle ungenxa yesenzo se-antioxidant esiza ukulwa nama-radicals mahhala.

isenzo sokulwa nokuvuvukala

Ngokwezinye izifundo, i-quercetin ingase ibe usizo ekubhekaneni nokuvuvukala, kodwa ngeshwa, ngisho nakulokhu, ubufakazi bulinganiselwe okwamanje.

Ingabe ingaba nezinzuzo ze-prostatitis?

Kwezinye izifundo, i-quercetin iye yamelana nokuvuvukala kwe-prostate.

Ingabe ingasekela uhlelo lwenhliziyo nemithambo yegazi?

I-Quercetin ingase ibe usizo kumfutho wegazi ovamile futhi ibe nezinye izinzuzo zempilo yenhliziyo nemithambo yegazi.

Ungayithatha kanjani futhi nini i-quercetin?

Umthamo obonisiwe kwezinye izifundo uyahluka phakathi kuka-100 no-1.000 mg ngosuku.

Yiziphi i-contraindication kanye nemiphumela emibi ye-quercetin?

Njengoba kunikezwe ukuntuleka kwezifundo, kunconywa ukuthi ungathathi i-quercetin ngesikhathi sokukhulelwa kanye ne-lactation.

Kuhlale kuwusizo ukubonana nodokotela wakho ngaphambi kokuthatha i-quercetin ukuze ukhethe ukwelashwa okufanele kakhulu. Umthamo onconyiwe akufanele weqiwe.

I-Hesperidin ne-quercetin

La hesperidin enye i-flavonoid lokho etholakala kakhulu kumawolintshi. Ebonakala ngemiphumela ye-antioxidant, izakhiwo ze-vasoprotective zibhekwa ngenxa yesenzo sayo ku-collagen kanye nezicubu ezixhunyiwe, ngakho-ke akuyona into engavamile ukuthola izithako emakethe ezihlanganisa ne-quercetin.

I-Hesperidin, izakhiwo kanye nezinzuzo

I-Hesperidin iyikhambi lemvelo ewusizo for microcirculation kanye nokuphazamiseka okuhlobene nohlelo lwenhliziyo nemithambo yegazi. Ama-hemorrhoids, imithambo ye-varicose, kodwa futhi i-cholesterol ephezulu ingazuza kakhulu kuyo.

Ukuwa, inkathi ye-citrus, ama-juice, i-vitamin C ... futhi ukucabanga ukuthi kunengxenye ye-citrus esingayicabangi, ngoba iyisikhumba, iyababa, icebile ngamafutha abalulekile: i isikhumba. Futhi kugobolondo lapho thola Enye ye-flavonoids esetshenziswa kakhulu phakathi kwezithako ze-antioxidant, i-hesperidin.

I-Hesperidin ikhona esikhumbeni nasesikhumbeni esimhlophe esingaphansi kwekhasi lezithelo ezisawolintshi. Ingxenye ethakazelisa kakhulu ye-hesperidin emkhakheni wezokwelapha kanye namakhambi isimisongenxa yezakhiwo zayo ze-vasoprotective.

Izakhiwo ze-Hesperidin

Izakhiwo ze-hesperidin zivezwa ku- microcirculation, emithanjeni yegazi nangale kwalokho. Ake sibone kangcono ukuthi yimiphi imisebenzi eyenziwa yile flavonoid:

• i-capillarotropic: amathoni ama-capillaries, avimbela ukuvuleka kwawo futhi asize ukuqinisa nokuthuthukisa isakhiwo se-capillary.
• i-vasoprotective: yenza ithoni kanye nesenzo sokuvikela emithanjeni yegazi, ivimbele i-atony yayo, ikhuthaza ukujikeleza kwe-venous nokwenza isenzo sokulwa nokuvuvukala.
• i-hypocholesterolemic: iyakwazi ukulungisa ukuphazamiseka kwe-metabolic futhi ikhuthaze ukukhiqizwa kwe-cholesterol enhle, nokulungiswa okulandelanayo kwezimo ze-hypertension kanye nokuvimbela izingozi zenhliziyo.

Izinzuzo ze-Hesperidin

Njengoba kulula ukuyiqonda, i-hesperidin ingaba ikhambi eliwusizo lokuvimbela nokwelapha ezinye iziphazamiso ezihlobene nokujikeleza kwemilenze engezansi, ukunwetshwa kwemikhumbi kanye ne-peripheral microcirculation..

abahluphekayo ukungasebenzi kahle kwe-venous ngezibonakaliso ezahlukene bangazuza kukho:

• ama-hemorrhoids: inkinga okuxoxwa ngayo kakhulu ehlanganisa i-vasodilation yangaphakathi noma yangaphandle ngokuvuvukala kwe-extroflexion kanye nokopha okungenzeka. I-Hesperidin iphikisana ne-atony yemikhumbi futhi ngaphezu kwakho konke ivimbela ukuvela kwayo kabusha.
• imithambo ye-varicose noma i-varicose: Kancane njengama-hemorrhoids, imithambo ye-varicose nayo iyimithambo enwetshiwe, inkinga evame ukuba nomthelela emaphethelweni aphansi, evame ukubhebhezelwa yi-venous stasis.

I-Hesperidin ithuthukisa imithambo yegazi, kuvimbela izifo ezingathí sina ezifana ne-phlebitis.

• i-capillary ephukile: ukuphazamiseka okuvamise ukuhlolwa kuphela ngomthelela waso wobuhle, kodwa okungase kubonise izifo ezibucayi kakhulu, kuzibonakalisa njengewebhu eluhlaza okwesibhakabhaka ebanzi kakhulu noma encane engavela emilenzeni, kodwa nasebusweni.

I-Hesperidin isiza ukuqinisa izindonga ze-capillary, kuvimbela ukwakheka kwemihuzuko futhi ikhuthaza ukuthuthukiswa kwamanethiwekhi.

• i-cholesterolemia: inzuzo esobala ibonakale endabeni yokwanda kwe-cholesterol ephelele ngocwaningo obelulindelwe ukuthatha i-hesperidin okungenani amaviki ama-4, ngesidingo sokukhiqizwa kwe-cholesterol enhle, ngenxa yalokho yehlisa eye-LDL.

Ungayithatha kanjani i-hesperidin

Kungenzeka ukuthola i-hesperidin njengekhambi elilodwa noma kusebenzisana nezinye izimiso ezisebenzayo eziqukethwe kumshanelo webhula, umvini obomvu, i-chestnut yamahhashi, i-sweet clover ne-gotu kola.

Umthamo onconyiwe wansuku zonke we-hesperidin ngu-500 mg ngosuku. Azikho contraindications noma side effectsNjengendlela yokuvimbela, ukusetshenziswa kwayo akukhuthazwa ngesikhathi sokukhulelwa kanye ne-lactation.

I-Quercetin ne-COVID-19

Mayelana ne-COVID-19, i-quercetin ikhonjiswe ukuthi isebenza ku-3CLpro, okungenye yamaprotheni abalulekile ekuphindaphindeni kwegciwane le-SARS-Cov-2, elikhubaza futhi okungenzeka livimbele ukuphindaphinda kwalo.

Umbono wami

Intshisekelo yabacwaningi ku-quercetin kanye, ngokujwayelekile, kwamanye ama-flavonoid aqukethwe ezithelweni nemifino iyabonakala.Siphinde sibone ngokucacile ukuthi abantu abajwayele ukusetshenziswa kakhulu kwezithelo nemifino bavame ukuqinisekisa ukwehla kwengozi ukuthuthukisa ezinye izinhlobo zomdlavuza. Ucwaningo lwamashubhu okuhlola namamodeli ezilwane lubonisa ezinye izakhiwo ezilwa nomdlavuza ze-flavonoids (i-quercetin namanye ama-flavonoid avimbela ukukhula kwamangqamuzana omdlavuza kumabele, ikholoni, i-prostate, i-ovarian, i-endometrial, nomdlavuza wamaphaphu), kodwa kuwumbono womlobi ukuthi ukuntuleka kobufakazi obulinganayo. umphumela kubantu cishe uhlobene neqiniso lokuthi i-quercetin isebenza ngokuphelele kumphumela oyinkimbinkimbi we-synergistic ohlanganisa eziningi (amakhulu? izinkulungwane?) ngobuningi, ukuze kuqinisekiswe ukugxila okuphezulu okuqhubekayo egazini naphezu kwesigamu sempilo emfushane yalezi zinto.

Ngamazwi alula, ngikholelwa ukuthi isihluthulelo somphumela wangempela wokuvimbela sisekusetshenzisweni kwansuku zonke kwezithelo nemifino, kunokuba emzamweni we-myopic wokukhiqiza imiphumela yawo kufomu lethebhulethi.

Izindlela zokusebenza

I-Quercetin kudala yakhanga intshisekelo yabacwaningi ngekhono layo lokwenza njenge-a inhibitor yemvelo yama-enzyme amaningi abantu. Ama-Enzymes ayizinto (ngokuvamile eziyingxenye yamaprotheni) ezikwazi ukukhuthaza isivinini sokusabela kwamakhemikhali, ngezinye izikhathi zisheshise ngendlela emangalisayo (kangangokuthi uma ingekho i-enzyme ukusabela bekungathatha isikhathi eside kangangokuthi bekungeke ngisho kubhekwe njengokuqhubekayo) .

Ngakho-ke, i-quercetin iyakwazi  ukukhiya noma yehlisa ijubane lokhu kusabela, okuhlanganisa:

• ukuguqulwa kwe-testosterone ku-dihydrotestosterone
• ukuguqulwa kwe-androgens ku-estrogens
• ukuhlanganiswa kwe-leukotrienes ne-arachidonic acid (ebandakanyeka ezenzweni zokuvuvukala)
• izindlela ezahlukahlukene ze-biochemical ezihlobene nokwanda kwamaseli.

Ngenxa yalesi sakhiwo sokugcina, kuvame ukuba yisizinda sokunakwa uma kuziwa ocwaningweni lomdlavuza, okungukuthi, ukucinga ama-molecule angaba izidakamizwa ezingaba yi-antitumor.

I-bioavailability ye-quercetin kubantu, okungukuthi, inani elake ladliwa lingena ngempela egazini, ngokuvamile liphansi futhi liyahlukahluka kakhulu (0-50%).

Izizathu zomehluko emiphumeleni phakathi kweshubhu/umzimba wokuhlola azihlali zicacile, kodwa phakathi kwemibono egunyazwe kakhulu, umehluko ku-bioavailability phakathi kwefomu lokudla kanye nefomu elivame ukusetshenziselwa ukulungisa izithasiselo (i-aglycone, ngenkathi ekudleni in use) kuyagqama.

Khona-ke isuswa ngokushesha, njengokuthi isigamu-ukuphila (isikhathi esithathayo ukubona isigamu sokuhlushwa egazini) amahora angu-1-2 kuphela (kungakhathaliseki ukuthi umthombo uwukudla noma isengezo). Futhi ngenxa yalesi sizathu, abacwaningi abaningi empeleni bayaqiniseka ukuthi ukusetshenziswa kokudla akuvumeli into ukuthi ibonise imiphumela ebonwa ku-vitro (ilabhorethri).

I-Quercetin Side Effects

I-Quercetin ithathwa njengephephile ngokunengqondo ukuthi isetshenziswe ukudla, kangangoba ngo-2010 i-FDA yase-US yabona ukuthi iphephile ngisho nasesimweni sokungezwa kuze kufike kumithamo engama-500 milligrams ngokuphakelwa ngakunye.

Esimeni semithamo ekhona ezithanjeni, ukuhlola kuyinkimbinkimbi kakhulu (futhi ngenxa yokuthi izikhathi eziningi lawa akhiwe aklanyelwe ukudla kwansuku zonke hhayi ngezikhathi ezithile njengasekudleni) futhi kunenani elinganele lomsebenzi wocwaningo lwe-toxicological. ukuphepha kwe-molecule) ukuze ufinyelele iziphetho eziqondile.

Eminye imithombo ibika ngokuthuthuka okungenzeka kwe ubuhlungu bekhanda kanye nokuphazamiseka kwamathumbu.

Ngokuvamile, nakuba abanye ababhali bephakamisa ukukhathazeka (ngokwesibonelo maqondana nengcuphe engase ibe khona yokuthuthukisa izimila ezincike ku-hormone), i-quercetin isabhekwa njengephephile kumithamo evame ukulindeleke ukuthi yengezwe kubantu abadala.

Contraindication

Ngenxa yesimiso sokuqapha (abukho ubufakazi bengozi noma ukuphepha) kunconywa ukugwema ukuthatha izithasiselo uma kwenzeka:

• abesifazane abakhulelwe nabancelisayo,
• izingane kanye nentsha.

Kodwa-ke, i-contraindicated ezigulini ezinezinkinga zezinso ezaziwayo.

Ukusebenzisana kwezidakamizwa

I-Quercetin iyi-inhibitor enamandla ye-cytochrome P3 enzymes CYP4A2 ne-CYP6D450, enye yezindlela ezibaluleke kakhulu ekusetshenzisweni kwezidakamizwa eziningi. Lokhu kusho ukuthi izidakamizwa ezisebenzisa le nqubo ukuze ziqedwe zingase zibe nemiphumela engaba yingozi, ibe nengozi enkulu yokubhekana nemiphumela engemihle. Ngamanye amazwi, Kuyanconywa ukuthi UNGATHATHI izithasiselo ezisekelwe ku-quercetin uma uthatha imithi egaywe yilawa ma-enzyme.s (imvamisa igqanyiswa kokufakwayo kwephakheji, ngoba ivame kakhulu).

Kunezinye izinyathelo zokuphepha okufanele zithathwe ngokuphathelene nezigaba ezithile zezidakamizwa, isibonelo:

• Imithi yomfutho wegazi ophakeme (njengoba abanye ababhali bephakamisa umphumela ongaba khona we-hypotensive, ukuhlotshaniswa nemithi ethathwe ngenjongo efanayo kungaholela ekwandeni kwemiphumela),
• imithi yesifo sikashukela (i-idem).