Abubuwan quercetin don jin daɗin ku

Quercetin (3,3,4,5,7-pentahydroxyflavone) ɗaya ne daga cikin metabolites na biyu da ke yaɗuwa a cikin masarautar shuka. Flavonoid quercetin shine polyphenol wanda ya ƙunshi zoben benzene guda uku da ƙungiyoyin hydroxyl biyar.

Szent-Gyorgyi ya fara ware Quercetin kuma ya gane shi a cikin shekara ta 1936. Tsarin sinadarai na quercetin shine C15H10O7. Tsarin yana da maɓallin flavonic da aka kafa ta zoben benzene guda biyu kuma an haɗa shi ta zoben pyronic heterocyclic; shi ne aglycone

An san wannan flavonoids yana da kaddarorin antioxidant kuma yana da aikin kariya daga tsufa. Ko da yake yana da aglycone kuma baya haɗa da nau'in carbohydrate, yana samuwa a cikin yanayi a cikin yanayin kyauta da haɗin kai. Alal misali, ana samun shi a cikin nau'i na glycoside a cikin abinci. Bayan an sha, glycoside yana hydrolyzed don saki aglycone, wanda aka shafe shi kuma ya daidaita shi zuwa wasu nau'in glucuronidated, sulfated, da methylated.

Properties physicochemical Properties

Kalmar "quercetum" kalma ce ta Latin don quercetin, wanda yana nufin fili mai launin rawaya. Wannan fili wani fili ne na crystalline mai ɗaci. Yana da sauƙi a narke a cikin lipid da barasa, wanda ba a iya narkewa a cikin ruwan sanyi, da rashin narkewa a cikin ruwan zafi.

A cikin yanayi ana samar da shi ta hanyar hanyar phenylpropanoid, wanda ke da amino acid phenylalanine a matsayin farkonsa. Matakan farko sun haɗa da haɗin cinnamic acid ta hanyar phenylalanine. Phenylalanine ammonia lyase yana taka muhimmiyar rawa wajen haɓaka halayen. Quercetin yana da ikon ba da gudummawar atom ɗinsa na hydrogen da kuma dakatar da ayyukan nau'ikan iskar oxygen. Yana hulɗa kai tsaye tare da hanyoyin siginar intracellular da ke da alhakin aikin antioxidant. Yawancin karatu a cikin vivo sun ba da shawarar cewa quercetin yana da ikon hana xanthine oxidase ta rage samuwar tsattsauran ra'ayi kuma don haka ana ɗaukarsa azaman antioxidant mai ƙarfi. A gaskiya ma, polyphenols irin su quercetin sun riga sun san su don rawar da suke ciki kare tantanin halitta daga oxidative danniya.

Bugu da ƙari, quercetin yana da lipophilic a cikin yanayi, don haka yana sauƙi ketare shingen jini-kwakwalwa kuma yana da aikin neuroprotective. Yana taka rawar kariya daga neurodegeneration. An san kwayoyin halittar don rage matakan glucose na jini da kiyaye aikin β cell a cikin berayen da berayen masu ciwon sukari. Yana nuna tasiri mai kyau akan jiyya da rigakafin ciwon sukari. Yawancin binciken in vitro da in vivo sun nuna cewa quercetin yana da aikin anticancer kuma za a iya amfani da shi azaman abin dogara magani a maganin ciwon daji. Quercetin yana da muhimmiyar rawa da zai taka a matsayin kwayoyin anti-mai kumburi.

Inda za a same shi a cikin abinci

Shuka iyalai kamar Solanaceae, Asteraceae, Passifloraceae da Rhamnaceae Suna da wadata a cikin abun ciki na quercetin. An fi samun Quercetin a cikin adadi mai yawa a cikin 'ya'yan itatuwa da kayan marmari daban-daban, ciki har da apples, berries, cherries, ja letas, albasa, bishiyar asparagus kuma a cikin ƙananan yawa a cikin barkono barkono, broccoli, Peas da tumatir. Hakanan an san yana kasancewa a cikin 'ya'yan itatuwa citrus, tsaba da kwayoyi, da inabi ja. Albasa yana da mafi girman adadin quercetin. Quercetin kuma an san yana kasancewa a cikin ganyaye irin su dill, wasu nau'ikan shayi, da giya. A cikin tsire-tsire kuma yana cikin Gingko, dattijon Amurka da Hypericum. Tsarin glycoside na quercetin ya hada da hyperoside, rutin, da isoquercetrin. Glycosidases suna da alhakin karya haɗin gwiwar glycosidic bayan cin abinci na baki.

Pharmacokinetics na quercetin

Bayan an sha, quercetin na iya haɗuwa da sunadaran salivary don samar da furotin mai narkewa-quercetin na binary aggregates. Bayan isa ga ƙananan hanji, quercetin yana raguwa ta hanyar lactate phlorizin hydrolase. Quercetin na iya shiga cikin sel epithelial ta hanyar watsawa lipophilicity dogara. Kafin shigar da tsarin jini, yawancin quercetin yana jujjuyawa zuwa metabolites masu haɗuwa. Binciken da aka yi kwanan nan ya nuna cewa microbiota na hanji yana shiga cikin samar da glycosidases da enzymes waɗanda ke canza quercetin zuwa ƙwayoyin ƙwayoyin cuta masu sauƙi.

Kusan 60% zuwa 81% na quercetin ana jigilar shi zuwa hanta ta cikin epithelium, inda aka daidaita shi kuma an canza shi zuwa nau'i na bioavailable. Galibin quercetin da metabolites dinsa ana fitar dasu ne ta hanji, amma kodan kadan ne ke fitar da su a cikin fitsari. Kawar da quercetin daga jiki yana da sauri sosai kuma an yi imanin yana da ɗan gajeren lokaci na jini.

A ƙasa na bayyana kaddarorin daban-daban na quercetin da tsarin aikin sa:

Properties da tsarin aiki

• anti-mai kumburi Properties: yana ƙara yawan maganganun kwayoyin IFN-γ (ta IFN muna nufin interferon) kuma yana rage ma'anar salon salula mai kyau na IL-4 (ta IL muna nufin interleukin);
• anti-ciwon daji Properties: yana haifar da hanyoyi na waje da na ciki na apoptosis, autophagy, da kama tsarin tantanin halitta;
• antioxidants: yana daidaita matakin GSH (GSH yana tsaye ga glutathione); yana rage matakin MDA (MDA yana tsaye ga malondialdehyde, ɗaya daga cikin samfuran ƙarshen polyunsaturated fatty acid peroxidation a cikin sel) kuma yana haɓaka ayyukan SOD (SOD = superoxide dismutase). Quercetin shine mai zazzagewa mai tsattsauran ra'ayi;
• antihypertensive: yana rage tsananin hawan jini ta hanyar rage matakan nitric oxide, TNF-α (TNF yana tsaye ga ƙwayar necrosis factor), da IL-6;
• ciwon sukari: Quercetin yana rage yawan matakan glucose na jini, yana kiyaye aikin cell cell, adadin ƙwayoyin β a cikin berayen masu ciwon sukari.
• neurodegenerative: Yana kawar da lalacewar oxidative neuronal da neuroinflammation kuma yana nuna antidementia da tasirin neuroprotective.

Kayan antioxidant

Saboda ƙungiyar phenolic hydroxyl da kasancewar haɗin gwiwa biyu, quercetin yana da ayyukan antioxidant masu yuwuwa. Abubuwan antioxidant na quercetin suna da alaƙa da rigakafi da maganin ciwon daji da cututtukan zuciya. Ƙungiyar hydroxyl a cikin tsarin quercetin yana aiki a matsayin mai ɓarna mai ɓarna. Ƙungiyar hydroxyl ta kwayoyin suna hana radicals kyauta ta hanyar samar da hydrogen mai aiki yayin da suke hana iskar shaka na fatty acid.

Saboda tsarin sinadarai, quercetin yana da ikon ɓata radicals na kyauta daban-daban ciki har da hydrogen peroxide, superoxide da hydroxyl radicals. Ƙungiyar catechol da ke cikin zobe B da ƙungiyar OH da ke cikin matsayi na 3 na zobe A suna ba da gudummawa ga dukiyar antioxidant na quercetin.

Quercetin yana kula da ma'auni na oxidative kuma saboda haka shine antioxidant mai karfi. Yana daidaita matakin GSH a cikin jiki. Har yanzu ba a bayyana ko quercetin yana gyara DNA ko yana kare shi daga lalacewar iskar oxygen ba. An gano tasirin antioxidant na quercetin-DNA ya fi na quercetin kadai.

Abubuwan da ke da cututtukan zuciya

Quercetin sanannen flavonoids ne wanda, lokacin da yake cikin wurare dabam dabam. yana inganta lafiyar jijiyoyin jini kuma idan ya kasance a cikin nau'i mai haɗuwa, yana rage faruwar cututtukan zuciya. Quercetin da sauran abubuwan da suka samo asali hana zubar jini da rage faruwar bugun jini, ban da samun aikin antioxidant don haka kare jiki daga damuwa na oxidative. An san shi yana tasiri da kwanciyar hankali da ruwa na lipid bilayer kuma yana rinjayar aikin mai jigilar furotin da ke dogara da ATP.

Hakanan yana da tasiri antihypertensives da vasodilators wanda ke fadada arteries, yana nuna mafi kyawun wurare dabam dabam. Maganin sa yana daidaita glucose na jini da matakan lipid yayin azumi, yana rage adadin kitse a cikin hanta, yana rage tsananin fibrosis na koda, kuma yana taka muhimmiyar rawa a cikin tsarin autophagy mai dogaro da AMPK. Mice masu kiba lokacin da ake ciyar da su tare da quercetin sun haifar da asarar nauyi da rage matakin triglyceride na plasma da matakin cholesterol kuma don haka inganta yanayin rayuwa. Rahotanni sun ba da shawarar sake haɗa fararen adipocytes zuwa adipocytes masu launin ruwan kasa.

Wannan yana da tsarin kariya daga osteoporosis, cututtukan huhu da cututtuka na venous.

Aiki akan cututtuka na autoimmune

An bayyana cewa Quercetin yana aiki m anti-mai kumburi effects, yafi ta hanyar hana samar da cytokine, rage yawan cyclooxygenase da lipoxygenase magana, da kuma kula da kwanciyar hankali na mast cell.

Mafi kyawun aikin antioxidant na quercetin yana aiki ne ta hanyar tasirin sa akan aikin glutathione, enzymes, da nau'in oxygen mai amsawa (ROS) da kuma ta hanyar daidaita hanyoyin siginar sigina, irin su heme-related factor 1 / nuclear erythroid oxygenase 2 (Nrf2), mitogen-activated protein kinase, toll-like receptor 4/phosphatidylinositol-3-kinase da adenosine monophosphate 5'- kunna furotin kinase.

Quercetin na iya rage ƙarfe mai daraja, wanda ke hana oxidation na lipid kuma yana kashe ROS, wanda yana taimakawa wajen hana kumburi da hana cututtuka masu alaƙa. Kalantari et al. ya ruwaito cewa quercetin yana da matukar tasiri wajen rage lalacewar hanta a cikin mice ta hanyar hana radicals kyauta da kuma daidaita matakan enzymes na antioxidant, ciki har da glutathione peroxidase, superoxide dismutase, da catalase. A ƙarshe, an ruwaito quercetin yana da tasirin neuroprotective da aikin antitumor.

Abubuwan da ke kan ciwo na rayuwa

Metabolic ciwo (MetS) wani hadadden cututtuka ne da ke haifar da mace-mace saboda ci gaban matsalolin zuciya. Quercetin, a matsayin muhimmin flavonoid, yana da daban-daban kaddarorin, kamar rage karfin jini, antihyperlipidemia, antihyperglycemia, antioxidant, antiviral, anticancer, anti-mai kumburi, antimicrobial, neuroprotective, da kuma cardioprotective.. A cikin wannan labarin sake dubawa (NAN), An tattara labaran asali daga tushe daban-daban, ciki har da Google Scholar, Medline, Scopus, da Pubmed, daidaita tasirin quercetin akan inganta alamun MetS, ciki har da glucose mai girma, hyperlipidemia, kiba, da hawan jini.

Dangane da waɗannan bayanan, quercetin na iya taka rawa wajen magance rikice-rikice na rayuwa ta hanyoyi da yawa, kamar ƙara yawan adiponectin, raguwar leptin, aikin antioxidant, rage juriya na insulin, haɓaka matakin insulin da toshewar tashoshi na calcium.

Yaushe ya kamata a dauka kuma ta yaya?

Yaushe za a dauki Quercetin? a lokuta da:

• Hypoimmunity.
• Cututtukan cututtukan cututtukan ƙwayar cuta na zamani.
• Sanyi
• Sinusitis.
• Masu tsattsauran ra'ayi.
• Ragewar capillary.

Haɗin gwiwar Haɗin kai: Me yasa Yafi Kyau

Za a iya inganta aikin quercetin mai amfani tare da:

Vitamin C da D

Haɗin kai tare da bitamin C zai zama alama ƙara da Quercetin bioavailability, Katse shigarwa, maimaitawa da aikin enzymatic na ƙwayar cuta kuma a lokaci guda yana tallafawa da ƙarfafa amsawar rigakafi. Haɗin gudanarwa na Quercetin da bitamin C dabarun gwaji ne don rigakafi da maganin ƙwayoyin cuta daban-daban na numfashi. Vitamin D yana da matukar amfani wajen rigakafi da magance cututtuka na numfashi na sama, da kuma mura na gargajiya.. Mun san cewa yana da ikon tallafawa tsarin rigakafi don haka ya sa ya fi dacewa da kwayar cutar. Bugu da ƙari, da alama cewa quercetin yana iya kunna mai karɓar bitamin D, wanda shine dalilin da ya sa suke haɗuwa.

Zinc da bromelain

Zinc zai iya rushe kumburi kuma ya rage haɗin tsakanin kwayar cutar da mai karɓa; yana kuma rage kwafi. Amma don shi, Zinc yana buƙatar ionophores waɗanda ke ba da izinin shiga cikin sel: quercetin daidai zinc ionophore ne.. Don haka wannan ƙungiyar tana ba da damar Zinc don haɓaka aikin rigakafin cutar. Nazarin kuma ya nuna cewa quercetin yana dacewa da bromelain a cikin cewa yana ƙarfafa aikin anti-mai kumburi ta hanyar haɓaka samar da prostaglandin. Idan aka haɗa su, don haka su ne tushen da ba makawa don tallafawa tsarin rigakafi.