Ƙara koyo game da cephalexin na karnuka da kuma yadda zai iya magance cututtuka masu kyau a cikin dabbobin gida ba tare da haifar da kowace irin lahani ga jikin dabba ba.
Menene cephalexin?
Cephalexin wani maganin rigakafi ne wanda aka nuna ana amfani dashi don maganin gurɓata daban-daban waɗanda ƙananan ƙwayoyin cuta suka haifar. Yana da magani na yau da kullun a cikin takardar sayan ɗan adam da na dabbobi, wato, cephalexin na karnukan da suka ɓace ana iya amfani da su musamman ga takamaiman marasa lafiya na ɗan adam.
Yana da mahimmanci cewa maganin rigakafi kawai ana fama da su tare da takardar sayan magani da kuma na yau da kullum da aka nuna ta hanyar likitancin likita, tun da, a gefe guda, dabba na iya gabatar da sakamakon da ke damun lafiyarsa. Yana da faffadan maganin rigakafin kamuwa da cuta. Musamman, cephalosporin ne na asali da ake tsammani.
Gabatarwa ce ta kasuwanci don rigakafin cututtukan beta-lactam wanda ke aiki a hukumance, a cikin Layer na cytoplasmic na ƙwayoyin cuta, ga sinadarai waɗanda ke da alhakin tsara mai rarraba tantanin halitta. Wannan yana hana su samun tsaro da kyau kuma yana haifar da bacewar ƙwayoyin cuta.
Cephalexin na canines daidai yake da na mutane, duk da haka, ana tallata shi a wuraren kiwon lafiya daban-daban, wasu a sarari don amfanin dabbobi. Misali, takamaiman yanayin cephalexin ga cats Yana da ƙayyadaddun sashi. Idan kare mara lafiya ne, yana da kyau a zabi takardar sayan magani don canines, tun da an yi nufin jinin jini.
Pharmacological Properties
Cephalexin yana aiki ta hanyar murƙushe haɗin nucleopeptic na mai rarraba ƙwayoyin cuta. Cephalosporins suna tsoma baki tare da mahaɗan transpeptiding ta hanyar hana peptidoglycan na hukuma daga ketare ɓangarorin zuwa mai rarraba tantanin halitta. Glycan giciye scaffolds sune na asali don haɓaka rarraba tantanin halitta.
Hannun biosynthesis yana haifar da raunin rabe-raben tantanin halitta, wanda a ƙarshe ya rushe ƙarƙashin nauyin osmotic. Ayyukan da aka ɗaure yana haifar da sel lysis da yanayin fiber. Cephalexin yana da ƙarfi a kan mafi yawan tasirin gram (+) (misali, Staphylococcus spp.) da Gram (-) (misali, Escherichia coli) ƙananan ƙwayoyin cuta.
Toshewar cephalexin na iya zama saboda ɗayan tsarin da ke biye. Da farko, ƙirƙirar cephalosporinases, wanda ke hana antitoxin ta hanyar hydrolysis na zoben beta-lactam, shine tsarin yau da kullun a tsakanin ƙwayoyin gram (-) ƙananan ƙwayoyin cuta. Ana ɗaukar wannan adawa ta plasmids ko chromosomally.
Bugu da ƙari, raguwar haɓakar PBPs (proteins masu ɗaure penicillin) don magungunan beta-lactam sau da yawa yana hade da beta-lactam toshewar ƙwayoyin cuta na Gram (+).
A ƙarshe, siphon masu fitar da ƙwayoyin cuta waɗanda ke fitar da antitoxin daga mai rarraba tantanin halitta, da canje-canje na asali a cikin pores, waɗanda ke rage tarwatsawar cephalosporin ba tare da hannu ba a cikin mai rarraba tantanin halitta, na iya ba da gudummawa ga faɗaɗa yanayin toshewar ƙwayar cuta.
Akwai sanannen toshewar giciye (kwatankwacin abubuwan da ke gaba da juna) tsakanin magungunan kashe kwayoyin cuta a cikin tarin beta-lactam, saboda kamanni na asali. Wannan yana faruwa tare da sinadarai na beta-lactamase, canje-canje na asali a cikin porins, ko iri a cikin siphon masu fitarwa. An ba da wakilcin haɗin gwiwa (ciki har da tsarin adawa daban-daban) a cikin E. coli saboda wasu halaye masu aminci waɗanda ke cikin plasmid.
Ingantattun bayanan fasaha
Bayan takardar sayan magani guda ɗaya na shawarar da aka ba da shawarar na 15 MG cephalexin a kowace kilogiram na nauyin jiki zuwa beagle hounds, an lura da gyaran plasma a cikin mintuna 30. An ga saman Plasma a 1.3 h tare da tsaka-tsakin plasma na 18.2 μg/mL.
Halin bioavailability na gyare-gyare mai ƙarfi ya kasance mafi ban mamaki fiye da 90%. An gano Cephalexin har zuwa awanni 24 bayan tsari. An yi gwajin fitsari na farko a wani wuri a cikin kewayon sa'o'i 2 da 12 tare da mafi girman mayar da hankali ga cephalexin daga 430 zuwa 2.758 µg/ml a cikin awanni 12.
Menene cephalexin da ake amfani dashi a cikin karnuka?
Da yake yana da maganin toxin, ana amfani da cephalexin na karnuka don yaƙi da cututtukan ƙwayoyin cuta waɗanda ƙwayoyin cuta ke haifar da su, daga cikinsu akwai streptococcus ko Salmonella. Saboda haka, yana da ƙarfi a kan ƙwayoyin microscopic na gram tabbatacce da tarurrukan korau na gram, duk da cewa, a cikin na ƙarshe da aka ambata, dacewa da wannan magani yana da mahimmanci.
Wannan maganin antitoxin ne mai yuwuwa kawai a cikin takamaiman cututtukan cututtuka, kamar yaƙin yaƙi da a demodectic mange, wannan shine dalilin da ya sa likitan dabbobi ya buƙaci shawarar amfani da shi. Babu wani hali da ya kamata a kwantar da kare ba tare da takardar sayan magani ba, žasa sosai idan ya zo ga maganin rigakafi.
Mummunan amfani da wannan miyagun ƙwayoyi yana haɓaka contraindications da kariyar da ke sa magungunan rigakafin da ke da ƙarfi, dalili a bayan dalilin da ya sa yana da mahimmanci a koma zuwa ga ma'auni masu ƙarfi, tare da duk haɗarin da wannan ke nunawa.
Cephalexin shine asalin cephalosporin wanda ake amfani da shi ta baki. Antitoxin ne da aka samu daga Cephalosporium acremonium. Yana aiki ta hanyar hana haɗuwar mucopeptide na masu rarraba ƙwayoyin ƙwayoyin cuta. Cefalexin ba shi da kariya ga staphylococcal beta-lactamases, kodayake yana kula da waɗanda ƙwayoyin cuta suka ƙirƙira na dangin Enterobacteriaceae.
Gwada kada a yi amfani da shi a cikin yara da ke da bango mai alamar hypersensitivity zuwa cephalosporins ko penicillins. Mummunan tasirin gabaɗaya ba gaskiya ba ne kuma maimaitawar su ba ta da yawa. A wasu halittu marasa tsaro yana iya haifar da dizziness, regurgitation, bacin rai ciki, gudu da anorexia.
Tsarin takardar sayan magani tare da abincin dare na iya rage waɗannan bayyanar cututtuka. Magungunan ya ƙetare fina-finai na placental, ba a warware shi tare da manufa ta musamman ba idan an kare shi don amfani a lokacin daukar ciki, duk da haka, ba a yi la'akari da yanayin teratogenicity ba.
Game da gazawar koda mara katsewa, ya kamata a faɗaɗa sarari tsakanin sassan bisa ga shawarar ƙwararren likitan dabbobi. Haɗarin haifar da wani nau'in cutarwa yana da ƙarancin ƙarancin gaske, la'akari da cewa LD 50 na baka a cikin rodents shine 5000 mg / kg na nauyi.
Tsarin Cephalexin don Kare da Nauyi
Sashin cephalexin zai dogara ne akan tsayin kowane canine da nauyin jikin dabba, tun da cephalexin syrup ba zai zama daidai da wani yanki da ake amfani da shi ta hanyar allura ko a cikin nau'in kwaya ba. Likitan likitancin dabbobi zai goyi bayan gabatarwar da ta fi dacewa ga kowane hali la'akari da ilimin cututtuka da kuma neman nau'in tsari mafi sauƙi kuma mafi banƙyama ga halitta.
Bugu da kari, duka nau'in gurɓataccen abu da ƙwayoyin cuta da ke haifar da ita, waɗanda mahallin dabbar na iya yin umarni da su, dole ne a yi la'akari da sashin takardar magani da jadawalin. Ana iya gudanar da Cephalexin kowane sa'o'i 12, dangane da matakan likitancin dabbobi.
Ku sani cewa cephalexin don amfani da baki an wajabta shi don gudanar da shi tare da abinci don guje wa mummunan tasirinsa, da gaske yana da alaƙa da ciki. Hakanan za'a iya raba shi don haɗuwa da abinci.
Yankin da aka kafa don kwas ɗin baka yana zuwa wani wuri a cikin kewayon 20 da 60 MG a kowace kilogiram na nauyin kare kuma ya kamata a kiyaye shi don kwanaki 5-7 bayan raguwar bayyanar cututtuka, kamar yadda likitan dabbobi zai nuna. Ana fitar da magungunan kuma suna wuce rabin wata. kada a yi watsi da su maganin rigakafiA yawancin lokuta suna da amfani.
Yana da mahimmanci cewa likitan dabbobi ya canza sashi, wanda dole ne a auna kare daidai, kuma yayi ƙoƙari kada ya ba shi gaba daya, tun da, idan adadin da aka tsara bai isa ba, ba zai yiwu ba.
Contraindications da illa na cephalexin ga karnuka
Cephalexin an hana shi ga duk karnukan da batattu ba su wuce gona da iri ga cephalosporins. Daga cikin alamun da ke nuna adawa da shi, mafi yawan ganewa shine wadanda ke da alaƙa da ciki lokacin da ake sarrafa cephalexin ta baki. Misali, ga lokuta inda nace zazzabi a cikin karnuka, ba a rubuta ba.
An wajabta bayar da wannan magani tare da abinci. Idan waɗannan tasirin ba su ragu ba ko kuma sun damu, yakamata a daina jinya kuma a sanar da likitan dabbobi nan da nan.
Ba a ba da shawarar bayar da cephalexin ga masu ciki ko masu shayarwa bitches ba, saboda babu wani bayani game da amincin sa a cikin embryos ko ƙananan karnuka. Likita ne kawai zai iya bincika haɗarin kuma ya yanke shawarar ko ya goyi bayansu ko a'a. Kwatankwacin yana faruwa tare da ƙwanƙolin jini suna fuskantar rashin jin daɗi na koda.