La i-lipidosis yesibindi I-feline ingenye yezifo ezivame kakhulu emakati.
Kuyisifo esibonakala ngokuthi a ukuqoqwa ngokweqile kwe-triglycerides esibindini eziphazamisa ukusebenza kwesibindi futhi ngokuvamile ziholela ekungasebenzi kahle kwezitho zomzimba.
Ukuqoqwa kwe-Triglyceride esibindini akuyona inkinga kuze kube yilapho izinga le-vacuolization liba nzima kakhulu. Amakati anesifo se-systemic avame ukuthuthukisa i-hepatocellular fat vacuolation.
Esibindini esivamile, okuqukethwe kwamafutha kungaphansi kuka-5% wesisindo esiphelele sesitho, ngenkathi usekati eline-hepatic lipidosis syndrome leli nani lingaphindeka kathathu. I-Hepatic triglycerides ikhiqizwa ngama-fatty acids atholakala ku-systemic circulation (ama-lipids okudla noma izitolo ze-adipose) kanye nakuma-hepatic synthesis.
Kufanele uqaphele kakhulu ngokukhuluphala
Gcina isisindo kwekati lakho elilawulwayo futhi ukuhlinzeka ngokudla okunempilo nokunomsoco kungavimbela i-lipidosis yesibindi. Emakatini, ukudla ngokweqile, okuvame ukubangelwa ikakhulukazi yi- ama-carbohydrate amaningi ekudleni, kungenxa yokunqwabelana kwamafutha ngaphakathi kwe-hepatocytes. Eqinisweni, amakati amaningi akha i-hepatic lipidosis akhuluphele.
Kwenzekani ngempela?
I-Hepatic lipidosis ibonisa ukungakwazi kwesitho ukulinganisa ukulahlekelwa kwamafutha nokudla okuvela emithonjeni yesistimu. Ibhalansi phakathi kwe-lipolysis kanye nokunqwabelana kwe-triglyceride ishintshwa yizinqubo zamahomoni nezinzwa. Ngokuqondile singakusho lokho i-hormone sensitive lipase (HSL), ethuthukisa i-lipolysis, kanye ne-lku-lipoprotein-lipase (LPL), ekhuthaza ukutholwa kwamafutha, ilawula ngokuqondile i-adipocyte metabolism.
Ama-catecholamines afana ne-norepinephrine, i-epinephrine, i-GH, i-glucagon, i-corticosteroids, ne-thyroxine andisa umsebenzi we-HSL, kuyilapho i-insulin iwuvimbela. Emakatini, ukucindezeleka kudala ukukhululwa ngokushesha kwama-catecholamine, okwandisa umsebenzi we-HSL. Ngaphansi kwezimo zokuzila ukudla isikhathi eside, nakuba umsebenzi we-LPI wehla, umsebenzi we-HSL uyakhula, uvumela ukuqoqwa kwamafutha ezingeni le-hepatocellular.
Iziphi izimbangela?
lipidosis kungenzeka okuyisisekelo, okungukuthi, zivele ngokuzenzakalelayo, ngaphandle kwesizathu esinembile esibonakalayo (ifomu le-idiopathic), noma okwesibili kwamanye ama-pathologies abangela i-anorexia nokuncipha kwesisindo kungazelelwe.
Ukuzila ukudla okulandela izimo ezihlukahlukene ze-pathological noma ezingezona ze-pathological, njengokwenqatshwa kokudla okusha okungathandeki, kuholela ekwandeni kokuhlanganiswa kwezitolo zamafutha kanye nokwanda komsebenzi we-metabolic wesibindi..
Ngaphansi kwezimo ezijwayelekile, isibindi sinomsebenzi wokwenza amafutha, njenge-triglycerides, i-cholesterol, ama-lipoprotein nama-phospholipids, kanye nokugawula amafutha (ama-acids anamafutha) akhona emzimbeni (izitolo zomzimba). Ukunqwabelana kwamafutha kwenzeka lapho ukwakheka kwesibindi noma ukugcinwa kuba kukhulu kakhulu kunomthamo wokusetshenziswa.
Ingozi eyengeziwe ye-lipidosis emakati akhuluphele futhi angadli
Ngenxa yalokho, a Ikati elikhuluphele elingaphansi kwengcindezi kanye nokuzila ukudla "okuzenzela". Ngokuqondile ngenxa yokucindezeleka, kuvezwa engcupheni enkulu yokuhlanganisa amafutha e-peripheral kanye nokuthathwa kwawo ezingeni le-hepatocellular.
Ukusebenzisana phakathi kwama-fatty acids kanye ne-L-carnitine ezingeni lolwelwesi lwe-mitochondrial, ukuze kukhululwe ngaphakathi kwe-mitochondria ngokwayo kanye nokwakheka kwama-acids acushiwe, adingekayo ku-beta oxidation, kungase futhi kube neqhaza ekuthuthukisweni kwe-syndrome. i-lipidosis yesibindi.
Ngaphezu kwalokho, ukuntuleka kwe-GSH kuma-hepatocyte kuhileleke ku-pathogenesis ye-lipidosis, okumelela ukungasebenzi endleleni ye-transsulfuration.
I-Vitamin B12 nayo idlala indima ebalulekile
Ekugcineni, kuye kwatholakala kaningi ukuntuleka kwevithamini B12 emakati ane-hepatic lipidosis.
Izimbangela ezingenzeka ze-hepatic lipidosis emakati, ngakho-ke futhi ngamafuphi, zibuyela ekwandeni kokwethulwa kwamafutha esibindini, ngenxa yokukhuluphala, ukuqalwa kwezimo ezibalulekile ze-catabolic ngenxa ye-pathologies eyisisekelo, ukungondleki okungapheli, ukugcizelela de novo hepatic synthesis yamafutha, noma ukuguqulwa kwe-oxidation noma ukuhlakazwa nge-VLDL.
Ngamafuphi ...
- ukudla ngokweqile, ikakhulukazi kuma-carbohydrate, ngokuvamile akhuphula ukunqwabelana kwe-lipid.
- Ukukhuluphala ngokweqile Kuyisici esandulelayo, esibaluleke kakhulu ekuthuthukiseni i-lipidosis yesibindi. Ekatini elikhuluphele elingenaso isifiso sokudla, ukukhululwa okukhulu kwama-fatty acids ezicutshini ezifakiwe kubeka ingcindezi ekhonweni lesibindi lokuwasebenzisa nokuwasusa.
- Ukwakhiwa kwama-lipoprotein aphansi kakhulu (VLDL) Kubalulekile ekuqedeni nasekuhlakazweni kwe-lipids. Ikhono lesibindi elikhubazekile ukwenza i-VLDL (edinga ukutholakala kwamandla okushodayo ku-lipidosis) kubangela ukunqwabelana okubalulekile kwe-triglyceride.
- Ukusebenzisana kwama-fatty acids ne I-L-carnitine kubalulekile ekuthuthweni kwama-fatty acids ku-mitochondria, ukuze kwenzeke i-beta oxidation (okungukuthi, ukusabela kokusetshenziswa kwamandla e-lipid). Amakati ane-hepatic lipidosis ngokuvamile ahlushwa ukushoda kwe-carnitine.
- Ukushoda kwe-Vitamin B12 (cobalamin) kuvame kakhulu ngesikhathi se-lipidosis.
Akusho lutho ukuthi bancane noma bakhulile.
i-lipidosis yesibindi ingathinta amakati anoma iyiphi iminyaka, ngaphandle kokukhetha ngokukhethekile uhlanga nobulili. Kodwa-ke, abesifazane abaneminyaka ephakathi noma asebekhulile babonakala bethinteka kakhulu kunabesilisa nabancane.
Singakuthola kanjani ukukubona?
Izimpawu ezimele kakhulu ngokuvamile phakathi ne-hepatic lipidosis yilezi ukuhlanza, ukucindezeleka, i-anorexia, nokulahlekelwa isisindo kungazelelwe. Esinye isibonakaliso somtholampilo esibaluleke kakhulu futhi esivame ukutholakala yi-jaundice, okungukuthi, umbala ophuzi wesikhumba nolwelwesi lwamafinyila.
Amakati ane-lipidosis ye-hepatic ngokuvamile aba buthaka kakhulu futhi angase abonise ngisho nokuphuma kwentamo noma i-recumbency unomphela. Kwezinye izimo, izimpawu ze-hepatic encephalopathy zingagqanyiswa, okungukuthi, izimpawu ze-neurological zilandela ukudakwa okuzenzakalelayo komzimba. Kwesinye isikhathi i-hepatic encephalopathy ingabonakaliswa yi-hypersalivation.
Kungase kube nezinye izifo ezibangela le lipidosis...
Kungase kube nezinye izifo ezifana nezifo ezithile zesibindi (isibonelo i-cholangitis), i-pancreatitis, izifo zesisu (ezibonakala ngokuhlanza nohudo), izimila noma isifo sikashukela esingase sibe phakathi kwezinkinga ezivame ukuhambisana ne-lipidosis.
Uma unekati elikhulu kakhulu futhi uqaphela ngisho neyodwa yalezi zimpawu, iseluleko siwukuvakashela udokotela wezilwane ngokushesha okuthi, ngemva kokuhlolwa okuphelele nokunakwa okukhethekile emlandweni wezokwelapha nokubonakala kwezimpawu, enze ukuxilongwa. Futhi ngakho-ke ungahlola ubulukhuni be-pathology.
Ukuhlolwa kwaselabhorethri nokunye ukuhlola ukuthola i-hepatic lipidosis
Bangenza izivivinyo eziningana ukuze bathole i-lipidosis njengalezi esixoxa ngazo ngezansi.
Ukuhlolwa kwegazi:
- inani legazi eliphelele, iphrofayili ye-biochemistry ejwayelekile: gI-Hyperbilirubinemia, ukwanda kwama-enzyme esibindi, ikakhulukazi ukwanda kwe-alanine aminotransferase (ALT), i-aspartate aminotransferase (AST), kanye ne-serum alkaline phosphatase (SAP) ngokuvamile kutholakala. I-Gamma glutamyl transferase (GGT) ivamise ukujwayelekile (ngaphandle uma kune-cholangitis ehambisanayo). Okunye okungavamile okutholakala kumelelwa i-hypokalemia, ukwehla kwe-BUN, i-hypophosphatemia, ngezinye izikhathi i-hypoalbuminemia, ne-hypocalcemia (ikakhulukazi ezimweni ezine-pancreatitis ehambisanayo).
- Ukuhlolwa kwe-coagulation: ukwanda kwezikhathi zokuhlangana kungabonwa njengoba isibindi sihilelekile ekuhlanganiseni izakhi ezivumela izinqubo zokuhlanganisa. Ngokukhethekile, phakathi ne-hepatic lipidosis, ukuntula kwe-vitamin K kuvame, ivithamini ebalulekile ukuze kusebenze izici zokuhlangana.
Ama-Radiographs: i-hepatomegaly (isibindi esandisiwe) singabonakala ekuhlolweni kwe-radiographic.
I-Ultrasoundography: Ukuhlolwa kwe-Ultrasound kungase kwembule isibindi esingavamile (i-hyperechoic) kanye nokuba khona kwama-pathologies ahlanganayo (isb., i-concomitant pancreatitis, cholangitis, noma neoplasia).
inaliti aspiration of isibindi: I-needle aspiration inqubo engenele kancane enganikeza ulwazi oluwusizo mayelana nokuba khona kokunqwabelana kwamafutha kumaseli esibindi (i-hepatocyte) futhi ikhiphe noma iyiphi i-tumor pathology engaphansi.
I-Biopsy Isibindi: I-biopsy yesibindi iyanconywa emakati angaphenduli ekwelashweni kokuqala noma lapho ama-biopsies eboniswa ukuze aphenye ezinye izinguquko zesitho.
Ukwelashwa ngokumelene ne-hepatic lipidosis
i-lipidosis yesibindi ngokuvamile iyabuyiseleka emuva uma iphathwa ngendlela efanele, kodwa ingelashwa ingaba yingozi kakhulu, ngezinye izikhathi iholele ekufeni. Ngakho-ke, izikhathi ezinde zokuzila akufanele zithathwe kancane. Ikakhulukazi uma ikati lakho likhuluphele futhi lingadli izinsuku ezimbalwa, kufanele usheshe uthintane nodokotela wakho wezilwane.
Ukuze uthole ukwelashwa okuphumelelayo, kubalulekile thola imbangela (ukuphazamiseka kwe-pancreas, isisu, amathumbu, i-bile ducts, njll.), uma kukhona, okungenzeka kubangele ukulahlekelwa ukudla okubangelwa i-hepatic lipidosis.
Ngokuvamile, amakati ane-hepatic lipidosis kanye ne-malaise enzima baqale badinge ukwelashwa esibhedlela bese balaliswa esibhedlela ukuze bathole ukunakekelwa okufanele.
Ngaphezu kokwelashwa kwembangela eyinhloko, lapho yaziwa, ukwelashwa kwe-electrolyte okungavamile okutholakele, ukubuyisela amanzi emzimbeni kanye nokulawula ukuhlanza, kubalulekile ukunikeza isilwane ukudla okunomsoco ngokudla ngenkani.
Ngaphezu kwalokho, i-vitamin supplementation inconywa neqembu amavithamini ancibilikayo emanzini, uvithamini K no-vitamin E. Okokugcina, ukuphathwa kwe-L-carnitine, i-taurine ne-S-adenosyl-methionine kanye/noma i-phytotherapeutic adjuvants kunconywa ukubuyisela ukusebenza kahle kwesibindi.