La quercetin yeyeqela lezinto ezinepolyphenolic ezaziwa ngokuba ziiflavonoids.

IiFlavonoids zafunyanwa sisazinzulu saseHungary uAlbert Szent-Györgyi, owafumana ivithamin C (waphumelela ibhaso leNobel leyeza kunye nePhysiology ngo-1937), owabona ukuba. i-flavonoids inefuthe le-synergistic kunye ne-vitamin C.

I-Quercetin yi-molecule ye-polyphenolic eveliswa yi-metabolism yezinye izityalo ezifana ne-chestnut yehashe, i-calendula, i-hawthorn, i-chamomile, i-wort yaseSt.

Iipropati zibalelwa antioxidants kunye ne-anticancer, phakathi kwabanye.

Singayifumana phi iquercetin?

I-Quercetin isasazwa ngokubanzi kubukumkani bezityalo: siyayifumana kwiziqhamo, amaxolo kunye neziqwenga yee-apula kunye anyanisi, i-cocoa, iziqhamo ezibomvu kunye ne-broccoli. Eyona mithombo ityebileyo ziziqhamo zesitrasi, ioli yomnquma, itswele, iwayini ebomvu, iti eluhlaza, kunye neSt.

I-quercetin esetyenziswa ngokuqhelekileyo kwizongezelelo zokutya ikhutshwa kwi-buds ye shopora japonica (isityalo sosapho UFabaceae – Iimbotyi) ekwaziwa njenge IRobinia yaseJapan, Umnga waseJapan okanye umthi wepagoda. Isityalo, semvelaphi yaseAsia (eChina naseKorea), ikhula kwindawo ezifudumeleyo nezipholileyo kwaye ikwandile kwimimandla yemozulu enemozulu epholileyo yaseYurophu.

Ekubeni shopora japonica ityebe kakhulu kwi-quercetin, kunokwenzeka ukuba ufumane isicatshulwa esicocekileyo. I-Quercetin ininzi isetyenziselwa ukuphazamiseka kwe-metabolic kunye nokuvuvukala kwaye owona msebenzi uphambili unxulunyaniswa ne-antioxidant.

Enyanisweni, inceda ukunciphisa ukubunjwa kwee-radicals zamahhala kunye ne-pro-inflammatory substances, ebonisa ukuba yintsebenziswano ebalulekileyo kwimpilo yethu. Ukongeza, iipropati zibalelwa kuyo i-vasoactive kuba inyusa ukuchasana kwee-capillaries kwaye ilawula ukunyanzeliswa kwayo.

Iziphumo zeQuercetin

I-Quercetin inemisebenzi elandelayo:

• anti-ukudumba,
• i-antiestrogenic,
• ukunciphisa ukwakheka kwezicubu ze-endometrial,
• ukunciphisa kakhulu uxinzelelo lwegazi lwe-systolic kwizigulane ze-borderline, ngakumbi ukuba zigqithise kakhulu,
• i-antiatherosclerotic ngokunqanda i-LDL oxidation kunye nomonakalo we-arterial endothelial,
• ukhuseleko lwe-cardio,
• i-antiviral,
• i-immunomodulator,
• i-anti-allergies,
• i-gastroprotective.

Ithathwa njani iquercetin?

I-Quercetin ifakwe emathunjini kwaye i-metabolites yayo ihanjiswa ngesibindi kwiintlobo ezahlukeneyo zomzimba. Kwiplasma ibophelela kwi-albumin. I Incopho yeplasma ifikelelwa malunga neeyure ezisi-7 emva kokungeniswa kwaye ukuphelisa isiqingatha-ubomi bumalunga neeyure ezingama-25. Ubukho be-quercetin ngomlomo akuqinisekanga: enyanisweni, kubonakala ngathi i-quercetin ingcono kwaye ifakwe ngokufanayo emathunjini ukuba ithathwa kunye namafutha afana ne-medium chain triglycerides. Yiyo loo nto kubalulekile ukuba izongezo ziqulethe izinto zelipid kwaye zithathwe kwisisu esigcweleyo.

Ngenxa yokuba uphando lwezenzululwazi lubonise ukuba ukutya okuphezulu kwe-flavonoids kunciphisa umngcipheko wezifo zenhliziyo kunye nokuba i-quercetin iyona nto ikhoyo ekudleni kwethu, kuyacetyiswa ukuba kusetyenziswe iziqhamo kunye nemifuno imihla ngemihla.

Ukuba ngokwenene isixa esaneleyo se-polyphenols asithathwanga okanye kwiimeko ezithile zempilo apho kuyimfuneko ukuba zithathwe kwiimali ezinkulu, ukusetyenziswa kwezongezelelo zokutya kunokubhenelwa kulo nje kuphela ziqulethe i-standardized, i-titrated extracts ezinxulumene nabakhuthazi be-absorption. oko kuthanda ukulinganisa.

Ukongeza, ubuninzi bemihla ngemihla obuvunyelwe nguMphathiswa wezeMpilo 200 mg yonke imihla kodwa, ngenxa yokusetyenziswa kwezinye iimveliso zezinto ezikhuthaza ukufunxwa kwayo, isixa esisezantsi siya kwanela.

Yeyiphi imithombo yendalo yequercetin?

I-Quercetin yenye yezona zinto zininzi ze-flavonoids zokutya, kangangokuba umyinge wokuthathwa kwemihla ngemihla ngokutya okuqhelekileyo kuqikelelwa ukuba malunga ne-25-50 milligrams.

Okunye kokutya / ukutya okuphezulu kwi-quercetin kubandakanya:

• i-capers (ngokumalunga nobunzima, sisityalo esiqulethe kakhulu, i-234 mg nge-100 g ye-buds eluhlaza),
• ibuckwheat,
• iidiliya ezimhlophe/ezibomvu
• iwayini ebomvu (enyanisweni, kumdiliya, oku kuhlanganiswa kuzo zombini iintlobo ezimhlophe nezibomvu, kodwa ngokubhekiselele kwiwayini, igxininiswe ngaphezu kwayo yonke iwayini ebomvu ngenxa yenkqubo yenguqu)
• Itswele elibomvu,
• Iti eluhlaza,
• i-blueberry,
• Apile,
• ipropolis,
• isileri,
• iradish,
• ikhaphetshu.
• ii-apile,
• umdiliya,
• kofu,
• amaqunube,
• ibrokholi,
• iziqhamo citric,
• kunye nama cherry.

Uninzi lwe-flavonoids ekutyeni luvela kwi-quercetin.

Eyona quercetin bioavailable kwaye ke ngoko ifaniswe ngcono yile yesikhumba se-apile.

Musa ukulahla amaqokobhe

Kufanelekile ukukhumbula ukuba kwi-anyanisi ebomvu iindawo eziphezulu ze-quercetin azifumaneki kuphela kwindawo esondeleyo kwingcambu, inxalenye yesityalo esinogxininiso oluphezulu, kodwa nakwiindandatho zangaphandle. Le nto ixhaphake kakhulu kwindalo kwaye ngumgaqo omele ungaze ulityalwe ekhitshini, ngakumbi xa silahla amaxolo kunye neengqimba zangaphandle zemifuno kunye neziqhamo ngokulula, silibale ukuba zimele imithombo exabisekileyo yezinto eziphilayo.

El Ukusetyenziswa kokutya okunamafutha kunye nemithombo yokutya ye-quercetin kubonakala kukwazi ukonyusa ukufunxa kwayo. esebenzayo, yona ngokwayo ilinganiselwe. Kwakhona ubukho be-carbohydrates, ngenxa yokukhuthazwa kwe-gastrointestinal motility kunye ne-fermentation phenomena emathunjini, kunokuba nefuthe elihle kulo mba.

I-quercetin iyichaphazela njani inkqubo yomzimba yokuzikhusela?

Le nto ineempawu ze-antiviral ezixhaswa zizifundo ezahlukeneyo kwiimodeli zezilwanyana, kodwa ngelishwa ukuza kuthi ga ngoku asiyazi eyona mpembelelo kunye nesenzo sale nto kwi-immune system.

Ukuqukumbela, ezinye iithiyori zikholelwa ukuba kunokuba luncedo kuphela phantsi kweemeko ezithile uxinzelelo olugqithisileyo lwengqondo.

Isetyenziselwa ntoni iquercetin?

Phakathi kwemiqondiso esetyenziswa kakhulu yi-anti-inflammatory kunye ne-antioxidant, ekhokelele ekusebenziseni kwiindawo ezininzi zonyango kunye neenjongo ezahlukeneyo:

• inkxaso ye-immune system,
• ukunciphisa ukuvuvukala,
• ukusebenza kwe-antitumor (ngaphezu kokuthintela),
• ukulawula iswekile yegazi,
• inkxaso yokusebenza kwezemidlalo
• ukuthintela izifo zentliziyo.

Iimpawu ezincinci ziquka:

• isifo samathambo,
• i-cystitis ye-interstitial,
• prostatitis.

I-Quercetin ifundwe kuphando olusisiseko (i-in vitro, oko kukuthi, kwiityhubhu zokuvavanya okanye umgca womda kwiimodeli zezilwanyana) kunye nezilingo ezincinci zeklinikhi (kubantu), kodwa ngelixa izongezo ziye zakhuthazwa ngokuphindaphindiweyo kunyango lomhlaza kunye nezinye izifo ezikhoyo ngoku. ubungqina obanelanga bomgangatho owaneleyo ukubonisa ukusebenza kakuhle okunokulinganiswa.

Njani kwaye nini ukuthatha i-quercetin ukuba uqhuba imidlalo?

Ukuxhaswa kwe-Quercetin kunokuxhasa kancinci umsebenzi wokuxhathisa umthambo.

Ngaba i-quercetin inesenzo sokulwa ne-antioxidant?

Umsebenzi omhle ngenxa yesenzo se-antioxidant esiza ukulwa nama-radicals amahhala.

isenzo esichasayo

Ngokutsho kwezinye izifundo, i-quercetin inokuba luncedo ekuchaseni ukuvuvukala, kodwa ngelishwa, nangona kulo mzekelo, ubungqina bulinganiselwe okwangoku.

Ngaba inokuba neenzuzo ze-prostatitis?

Kwezinye izifundo, i-quercetin ichasene nokuvuvukala kwe-prostate.

Ngaba inokuxhasa inkqubo ye-cardiovascular system?

I-Quercetin inokuba luncedo kuxinzelelo lwegazi oluqhelekileyo kwaye ibe nezinye izibonelelo zempilo ye-cardiovascular.

Njani kwaye nini ukuthatha i-quercetin?

I-dose ebonisiweyo kwezinye izifundo iyahluka phakathi kwe-100 kunye ne-1.000 mg ngosuku.

Ziziphi ii-contraindications kunye nemiphumo emibi ye-quercetin?

Ngenxa yokungabikho kwezifundo, kucetyiswa ukuba ungathathi i-quercetin ngexesha lokukhulelwa kunye ne-lactation.

Kuhlala kuluncedo ukubonisana nogqirha wakho ngaphambi kokuba uthathe i-quercetin ukukhetha unyango olufanelekileyo. Ithamo elicetyiswayo kufuneka lingagqithiswa.

Hesperidin kunye nequercetin

La yeykiso yenye flavonoid leyo ifumaneka ikakhulu kwi-citrus. Ebonakaliswe yimiphumo ye-antioxidant, iimpawu ze-vasoprotective zibangelwa ngenxa yesenzo sayo kwi-collagen kunye nezicubu ezidibeneyo, ngoko ke akuqhelekanga ukufumana izongezo kwiimarike ezidibanisa ne-quercetin.

Hesperidin, iipropati kunye neenzuzo

I-Hesperidin liyeza lendalo luncedo kwi-microcirculation kunye nokuphazamiseka okunxulumene nenkqubo ye-cardiovascular system. I-Hemorrhoids, imithambo ye-varicose, kodwa kunye ne-cholesterol ephezulu inokuzuza kakhulu kuyo.

Ukuwa, ixesha lesitrasi, ijusi, i-vitamin C ... kunye nokucinga ukuba kukho inxalenye ye-citrus esingayithathi ingqalelo, kuba i-leathery, ikrakra, icebile kwioli efunekayo: i piel. Kwaye ikwiqokobhe apho fumana Enye yezona zinto zisetyenziswa kakhulu kwi-flavonoids phakathi kwezongezo ze-antioxidant, i-hesperidin.

I-Hesperidin ikhona eluswini kunye nesikhumba esimhlophe sangaphantsi kwe-peel yeziqhamo ze-citrus. Inxalenye enomdla kakhulu ye-hesperidin kwintsimi yamachiza kunye nemifuno isiqhelongenxa yeempawu zayo ze-vasoprotective.

Iipropati zeHesperidin

Iimpawu ze-hesperidin zibonakaliswe kwi microcirculation, kwimithambo yegazi nangaphezulu. Makhe sibone ngcono ukuba yeyiphi imisebenzi eyenziwa yile flavonoid:

• i-capillarotropic: iithoni ze-capillaries, zithintela ukuhlanjululwa kwazo kwaye zinceda ukuqinisa nokuphuhlisa isakhiwo se-capillary.
• vasoprotective: yenza ithoni kunye nesenzo sokukhusela kwimithambo yegazi, ukuthintela i-atone yabo, ukuvuselela ukujikeleza kwe-venous kunye nokwenza isenzo esichasayo.
• i-hypocholesterolemic: iyakwazi ukulungisa ukuphazamiseka kwemetabolism kunye nokukhuthaza ukuveliswa kwe-cholesterol enhle, kunye nokulungiswa kwesiphumo se-hypertension kunye nokuthintela umngcipheko we-cardiovascular.

IiNzuzo zeHesperidin

Njengoko kulula ukuyiqonda, i-hesperidin ingaba iyeza eliluncedo lokuthintela kunye nokunyanga ezinye iziphazamiso ezinxulumene nokujikeleza kwemilenze engezantsi, ukunwenwa kwemikhumbi kunye ne-peripheral microcirculation..

ababandezelekileyo ukungoneli kwe-venous kunye nemiboniso eyahlukeneyo banokuzuza kuyo:

• hemorrhoids: ingxaki exoxwe kakhulu ebandakanya i-vasodilation yangaphakathi okanye yangaphandle kunye nokuvuvukala kwe-extroflexion kunye nokuphuma kwegazi. I-Hesperidin iphikisana ne-atoni yeenqanawa kwaye ngaphezu kwayo yonke into ikhusela ukuvela kwabo kwakhona.
• imithambo ye-varicose okanye i-varicose: Kancinci njenge-hemorrhoids, i-varicose veins nayo i-veins ehlanjululweyo, ingxaki ehlala ichaphazela imilenze ephantsi, idla ngokugqithiswa yi-venous stasis.

I-Hesperidin ikhupha imithambo, ikhuthaza ukujikeleza, kuthintela izifo ezinzulu ezifana ne-phlebitis.

• i-capillary ebuthathaka: Ukuphazamiseka okuhlala kuvavanywa kuphela ngenxa yempembelelo yayo yobuhle, kodwa enokubonisa iipathologies ezinzulu ngakumbi, izibonakalisa njengewebhu eblush ebanzi kakhulu okanye encinci enokubonakala emilenzeni, kodwa nasebusweni.

I-Hesperidin inceda ukuqinisa iindonga ze-capillary, kuthintela ukubunjwa kwamanxeba kwaye ikhuthaza uphuhliso lothungelwano.

• cholesterolemia: inzuzo ebonakalayo ibonwe kwimeko yokunyuka kwe-cholesterol epheleleyo ngezifundo ezilindelekileyo ukuthatha i-hesperidin ubuncinane kwiiveki ezi-4, nemfuneko yokuveliswa kwe<em>cholesterol elungileyo, nto leyo ebangela ukuba yehlise iLDL.

Uyithatha njani i-hesperidin

Kuyenzeka ukuba ufumane i-hesperidin njengeyeza elilodwa okanye kwintsebenziswano kunye neminye imigaqo esebenzayo equlethwe kumtshayelo kabhula, umdiliya obomvu, i-chestnut yehashe, i-sweet clover kunye ne-gotu kola.

I-dose yemihla ngemihla ekhuthazwayo ye-hesperidin yi-500 mg yonke imihla. Akukho contraindications okanye iziphumo ebezingalindelekangaNjengomlinganiselo wokuthintela, ukusetyenziswa kwayo akukhuthazwa ngexesha lokukhulelwa kunye ne-lactation.

Quercetin kunye ne-COVID-19

Ngokumalunga ne-COVID-19, kubonisiwe ukuba i-quercetin isebenza kwi-3CLpro, enye yeeproteni ezibalulekileyo zokuphindaphinda intsholongwane ye-SARS-Cov-2, iyenza ingazinzi kwaye inokuthintela ukuphindaphinda kwayo.

Uluvo lwam

Umdla wabaphandi kwi-quercetin kwaye, ngokubanzi, kwezinye i-flavonoids eziqulethwe kwiziqhamo kunye nemifuno.Sibona ngokucacileyo ukuba izifundo eziqhele ukusetyenziswa kakhulu kweziqhamo kunye nemifuno zikholisa ukuqinisekisa ukunciphisa umngcipheko phuhlisa ezinye iintlobo zomhlaza. Uphononongo kwiityhubhu zovavanyo kunye neemodeli zezilwanyana zibonisa iipropathi ezithile ze-anticancer ze-flavonoids (i-quercetin kunye nezinye i-flavonoids zithintela ukukhula kweeseli zomhlaza kwibele, kwikholoni, kwi-prostate, kwi-ovarian, kwi-endometrial, nakwimiphunga yomhlaza wemiphunga), kodwa luluvo lombhali ukuba ukungabikho kobungqina obulinganayo. Impembelelo ebantwini mhlawumbi inxulumene nento yokuba i-quercetin isebenza ngokubanzi kwisiphumo esiyinkimbinkimbi ye-synergistic ebandakanya ezininzi (amakhulu? amawaka?) Ezinye izinto ezisebenzayo eziqulethwe kwiziqhamo kunye nemifuno, kwaye enokuthi ibonise umphumo obambekayo kuphela xa idliwe rhoqo kwaye ngobuninzi obuninzi, ukuze kuqinisekiswe ukugxila okuphezulu okuthe gqolo egazini ngaphandle kobomi obufutshane besiqingatha sobomi bezi zinto.

Ngamazwi alula, ndikholelwa ukuba isitshixo kwisiphumo soqobo sokuthintela sisekusetyenzisweni kwansuku zonke kweziqhamo kunye nemifuno, kunokuba kumzamo we-myopic wokuvelisa iziphumo zabo kwifom yethebhulethi.

Iindlela zokusebenza

I-Quercetin kudala itsala umdla wabaphandi ngokukwazi kwayo ukwenza njenge inhibitor yendalo yee-enzymes ezininzi zabantu. Ii-Enzymes zizinto (ngokuqhelekileyo ziyiprotein nature) ezikwaziyo ukukhuthaza isantya sokusabela kweekhemikhali, ngamanye amaxesha ukukhawulezisa ngokukhawuleza (kangangokuba xa ingekho i-enzayimi ukusabela kuya kuthatha ixesha elide kangangokuba bekungayi kuthathwa njengokuqhubekayo) .

Ngoko ke, i-quercetin iyakwazi  ukuvala okanye ucothise ezi mpendulo, kuquka:

• ukuguqulwa kwe testosterone kwi-dihydrotestosterone
• ukuguqulwa kwe-androgens kwi-estrogens
• ukuhlanganiswa kwe-leukotrienes kunye ne-arachidonic acid (ebandakanyeka kwizinto ezivuthayo)
• iindlela ezahlukeneyo ze-biochemical ezinxulumene nokwanda kweeseli.

Enkosi kule propathi yokugqibela, ihlala iyindawo yengqwalasela xa kufikwa kuphando lomhlaza, oko kukuthi, ukukhangela iimolekyuli ezinokuthi zibe amachiza anokubakho e-antitumor.

I-bioavailability ye-quercetin ebantwini, oko kukuthi, imali esele idliwe ngokwenene ingena egazini, iphantsi kwaye iguquguquke kakhulu (0-50%).

Izizathu zokungahambelani kwimiphumo phakathi kwetyhubhu yokuvavanya / i-organism ayisoloko icacile, kodwa phakathi kweengcamango ezivunyiweyo, umahluko kwi-bioavailability phakathi kwefom yokutya kunye nefom esetyenziswa ngokuqhelekileyo ukulungiselela izongezelelo (i-aglycone, ngelixa ukutya kukutya). isetyenziswa) ibalasele.

Emva koko kupheliswa ngokukhawuleza, ukuba isiqingatha-ubomi (ixesha elithathayo ukubona isiqingatha soxinaniso egazini) kuphela iiyure ezingama-1-2 (kungakhathaliseki ukuba umthombo kukutya okanye isongezelelo). Kwakhona ngenxa yesi sizathu, abaphandi abaninzi baqinisekile ukuba ukusetyenziswa kokutya akuvumeli into ukuba ibonise iziphumo ezibonwe kwi-vitro (i-laboratory).

I-Quercetin ye-Side Effects

I-Quercetin ithathwa njengekhuselekile ngokufanelekileyo ekutyeni kokutya, kangangokuba ngo-2010 i-FDA yase-US yayibona njengekhuselekile nakwimo yokongeza ukuya kuthi ga kwiidosi ezingama-500 eemiligram ngokuphakwa.

Kwimeko yamathamo akhoyo kwizongezo, uvandlakanyo luntsonkothe ​​ngakumbi (kwakhona ngenxa yokuba amaxesha amaninzi ezi ziyimixube eyilelwe ukuthathwa kwemihla ngemihla kwaye hayi ngamaxesha athile njengasekutyeni) kwaye kukho umyinge ongonelanga womsebenzi wophando ngetyhefu (okt kugxininiswe kunyango lwetyhefu). ukhuseleko lwemolekyuli) ukwenza izigqibo eziqinisekileyo.

Eminye imithombo inika ingxelo ngophuhliso olunokwenzeka lwe intloko ebuhlungu kunye nokuphazamiseka kwesisu.

Ngokubanzi, nangona abanye ababhali bephakamisa iinkxalabo (umzekelo ngokunxulumene nomngcipheko onokwenzeka wokukhuthaza amathumba axhomekeke kwihomoni), i-quercetin isathathwa njengekhuselekile kwiidosi ezilindeleke ukuba zongezwe kubantu abadala.

Unxibelelwano

Ngenxa yomgaqo wokhuseleko (akukho bungqina bengozi okanye ukhuseleko) kuyacetyiswa ukuba uphephe ukuthatha izongezo xa kwenzeka:

• abafazi abakhulelweyo nabancancisayo,
• abantwana nabafikisayo.

Nangona kunjalo, i-contraindicated kwizigulane ezineengxaki zezintso ezaziwayo.

Ukusebenzisana kweziyobisi

I-Quercetin i-inhibitor enamandla ye-cytochrome P3 enzymes CYP4A2 kunye ne-CYP6D450, enye yezona ndlela zibalulekileyo kwi-metabolism yamachiza amaninzi. Oku kuthetha ukuba amachiza asebenzisa le ndlela yokupheliswa anokubandezeleka ngenxa yeziphumo ezinokwenzeka, kunye nomngcipheko omkhulu wokufumana iziphumo ebezingalindelekanga. Ngamanye amazwi, Kuyacetyiswa ukuba UNGATHATHI izongezo ezisekelwe kwi-quercetin ukuba uthatha amayeza axutywe zezi enzymes.s (idla ngokubalaseliswa kufakelo lwepakethe, ngokuchanekileyo kuba zixhaphake kakhulu).

Kukho amanye amanyathelo okhuseleko ekufuneka athatyathwe ngokubhekiselele kwiindidi ezithile zamachiza, umzekelo:

• Amayeza oxinzelelo lwegazi oluphezulu (ekubeni abanye ababhali becebisa isiphumo esinokwenzeka se-hypotensive, ukunxibelelana namayeza athathelwe injongo enye kunokukhokelela ekwandeni kweziphumo),
• amayeza esifo seswekile (idem).